Extended-Spectrum {beta}-Lactamases in the 21st Century: Characterization, Epidemiology, and Detection of This Important Resistance Threat

doi:10.1128/CMR.14.4.933-951.2001

This Article

	Full Text
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager
	Reprints and Permissions
	Copyright Information
	Books from ASM Press
	MicrobeWorld

Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Bradford, P. A.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Bradford, P. A.

Clinical Microbiology Reviews, October 2001, p. 933-951, Vol. 14, No. 4
0893-8512/01/$04.00+0 DOI: 10.1128/CMR.14.4.933-951.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Extended-Spectrum $beta$ -Lactamases in the 21st Century: Characterization, Epidemiology, and Detection of This Important Resistance Threat

Patricia A. Bradford^*

Wyeth-Ayerst Research, Pearl River, New York

$beta$ -Lactamases continue to be the leading cause of resistance to $beta$ -lactam antibiotics among gram-negative bacteria. In recentyears there has been an increased incidence and prevalence ofextended-spectrum $beta$ -lactamases (ESBLs), enzymes that hydrolyzeand cause resistance to oxyimino-cephalosporins and aztreonam.The majority of ESBLs are derived from the widespread broad-spectrum $beta$ -lactamases TEM-1 and SHV-1. There are also new families of ESBLs,including the CTX-M and OXA-type enzymes as well as novel, unrelated $beta$ -lactamases. Several different methods for the detection of ESBLsin clinical isolates have been suggested. While each of the testshas merit, none of the tests is able to detect all of the ESBLsencountered. ESBLs have become widespread throughout the worldand are now found in a significant percentage of Escherichia coliand Klebsiella pneumoniae strains in certain countries. They havealso been found in other Enterobacteriaceae strains and Pseudomonasaeruginosa. Strains expressing these $beta$ -lactamases will presenta host of therapeutic challenges as we head into the 21stcentury.

^* Mailing address: Wyeth-Ayerst Research, 401 N. Middletown Rd., Pearl River, NY 10965. Phone: (845) 732-4386. Fax: (845) 732-5671.E-mail: bradfop{at}war.wyeth.com.

This article has been cited by other articles:

Celenza, G., Luzi, C., Aschi, M., Segatore, B., Setacci, D., Pellegrini, C., Forcella, C., Amicosante, G., Perilli, M. (2008). Natural D240G Toho-1 mutant conferring resistance to ceftazidime: biochemical characterization of CTX-M-43. J Antimicrob Chemother 62: 991-997 [Abstract] [Full Text]
Livermore, D. M., Mushtaq, S., Warner, M., Miossec, C., Woodford, N. (2008). NXL104 combinations versus Enterobacteriaceae with CTX-M extended-spectrum {beta}-lactamases and carbapenemases. J Antimicrob Chemother 62: 1053-1056 [Abstract] [Full Text]
Karami, N., Hannoun, C., Adlerberth, I., Wold, A. E. (2008). Colonization dynamics of ampicillin-resistant Escherichia coli in the infantile colonic microbiota. J Antimicrob Chemother 62: 703-708 [Abstract] [Full Text]
Hanson, N. D., Moland, E. S., Hong, S. G., Propst, K., Novak, D. J., Cavalieri, S. J. (2008). Surveillance of Community-Based Reservoirs Reveals the Presence of CTX-M, Imported AmpC, and OXA-30 {beta}-Lactamases in Urine Isolates of Klebsiella pneumoniae and Escherichia coli in a U.S. Community. Antimicrob. Agents Chemother. 52: 3814-3816 [Abstract] [Full Text]
Wright, B. M., Eiland, E. H. III (2008). Current Perspectives on Extended-Spectrum Beta-Lactamase-Producing Gram-Negative Bacilli. Journal of Pharmacy Practice 21: 338-345 [Abstract]
Bethel, C. R., Distler, A. M., Ruszczycky, M. W., Carey, M. P., Carey, P. R., Hujer, A. M., Taracila, M., Helfand, M. S., Thomson, J. M., Kalp, M., Anderson, V. E., Leonard, D. A., Hujer, K. M., Abe, T., Venkatesan, A. M., Mansour, T. S., Bonomo, R. A. (2008). Inhibition of OXA-1 {beta}-Lactamase by Penems. Antimicrob. Agents Chemother. 52: 3135-3143 [Abstract] [Full Text]
Tumbarello, M., Sali, M., Trecarichi, E. M., Leone, F., Rossi, M., Fiori, B., De Pascale, G., D'Inzeo, T., Sanguinetti, M., Fadda, G., Cauda, R., Spanu, T. (2008). Bloodstream Infections Caused by Extended-Spectrum-{beta}-Lactamase- Producing Escherichia coli: Risk Factors for Inadequate Initial Antimicrobial Therapy. Antimicrob. Agents Chemother. 52: 3244-3252 [Abstract] [Full Text]
Kiratisin, P., Apisarnthanarak, A., Laesripa, C., Saifon, P. (2008). Molecular Characterization and Epidemiology of Extended-Spectrum- {beta}-Lactamase-Producing Escherichia coli and Klebsiella pneumoniae Isolates Causing Health Care-Associated Infection in Thailand, Where the CTX-M Family Is Endemic. Antimicrob. Agents Chemother. 52: 2818-2824 [Abstract] [Full Text]
Haanpera, M., Forssten, S. D., Huovinen, P., Jalava, J. (2008). Typing of SHV Extended-Spectrum {beta}-Lactamases by Pyrosequencing in Klebsiella pneumoniae Strains with Chromosomal SHV {beta}-Lactamase. Antimicrob. Agents Chemother. 52: 2632-2635 [Abstract] [Full Text]
Empel, J., Baraniak, A., Literacka, E., Mrowka, A., Fiett, J., Sadowy, E., Hryniewicz, W., Gniadkowski, M., and the Beta-PL Study Group, (2008). Molecular Survey of {beta}-Lactamases Conferring Resistance to Newer {beta}-Lactams in Enterobacteriaceae Isolates from Polish Hospitals. Antimicrob. Agents Chemother. 52: 2449-2454 [Abstract] [Full Text]
Rotimi, V. O., Jamal, W., Pal, T., Sovenned, A., Albert, M. J. (2008). Emergence of CTX-M-15 type extended-spectrum {beta}-lactamase-producing Salmonella spp. in Kuwait and the United Arab Emirates. J Med Microbiol 57: 881-886 [Abstract] [Full Text]
Davidson, A. L., Dassa, E., Orelle, C., Chen, J. (2008). Structure, Function, and Evolution of Bacterial ATP-Binding Cassette Systems. Microbiol. Mol. Biol. Rev. 72: 317-364 [Abstract] [Full Text]
Mendonca, N., Manageiro, V., Robin, F., Salgado, M. J., Ferreira, E., Canica, M., Bonnet, R. (2008). The Lys234Arg Substitution in the Enzyme SHV-72 Is a Determinant for Resistance to Clavulanic Acid Inhibition. Antimicrob. Agents Chemother. 52: 1806-1811 [Abstract] [Full Text]
Pop-Vicas, A., Strom, J., Stanley, K., D'Agata, E. M.C. (2008). Multidrug-Resistant Gram-Negative Bacteria among Patients Who Require Chronic Hemodialysis. CJASN 3: 752-758 [Abstract] [Full Text]
Perez-Llarena, F. J., Cartelle, M., Mallo, S., Beceiro, A., Perez, A., Villanueva, R., Romero, A., Bonnet, R., Bou, G. (2008). Structure-function studies of arginine at position 276 in CTX-M {beta}-lactamases. J Antimicrob Chemother 61: 792-797 [Abstract] [Full Text]
Giske, C. G., Monnet, D. L., Cars, O., Carmeli, Y., on behalf of ReAct-Action on Antibiotic Resistance, (2008). Clinical and Economic Impact of Common Multidrug-Resistant Gram-Negative Bacilli. Antimicrob. Agents Chemother. 52: 813-821 [Full Text]
Perilli, M., Celenza, G., De Santis, F., Pellegrini, C., Forcella, C., Rossolini, G. M., Stefani, S., Amicosante, G. (2008). E240V Substitution Increases Catalytic Efficiency toward Ceftazidime in a New Natural TEM-Type Extended-Spectrum {beta}-Lactamase, TEM-149, from Enterobacter aerogenes and Serratia marcescens Clinical Isolates. Antimicrob. Agents Chemother. 52: 915-919 [Abstract] [Full Text]
Bos, F., Pleiss, J. (2008). Conserved Water Molecules Stabilize the {Omega}-Loop in Class A {beta}-Lactamases. Antimicrob. Agents Chemother. 52: 1072-1079 [Abstract] [Full Text]
Hammond, D. S., Harris, T., Bell, J., Turnidge, J., Giffard, P. M. (2008). Selection of SHV Extended-Spectrum-{beta}-Lactamase-Dependent Cefotaxime and Ceftazidime Resistance in Klebsiella pneumoniae Requires a Plasmid-Borne blaSHV Gene. Antimicrob. Agents Chemother. 52: 441-445 [Abstract] [Full Text]
Fang, H., Ataker, F., Hedin, G., Dornbusch, K. (2008). Molecular Epidemiology of Extended-Spectrum {beta}-Lactamases among Escherichia coli Isolates Collected in a Swedish Hospital and Its Associated Health Care Facilities from 2001 to 2006. J. Clin. Microbiol. 46: 707-712 [Abstract] [Full Text]
Bhattacharjee, A., Sen, M. R., Prakash, P., Anupurba, S. (2008). Role of {beta}-lactamase inhibitors in enterobacterial isolates producing extended-spectrum {beta}-lactamases. J Antimicrob Chemother 61: 309-314 [Abstract] [Full Text]
Berg, M. L, Crank, C. W, Philbrick, A. H, Hayden, M. K (2008). Efficacy of Ertapenem for Consolidation Therapy of Extended-Spectrum {beta}-lactamase-Producing Gram-Negative Infections: A Case Series Report. The Annals of Pharmacotherapy 42: 207-212 [Abstract] [Full Text]
Neuberger, A., Oren, I., Sprecher, H. (2008). Clinical Impact of a PCR Assay for Rapid Identification of Klebsiella pneumoniae in Blood Cultures. J. Clin. Microbiol. 46: 377-379 [Abstract] [Full Text]
Golebiewski, M., Kern-Zdanowicz, I., Zienkiewicz, M., Adamczyk, M., Zylinska, J., Baraniak, A., Gniadkowski, M., Bardowski, J., Ceglowski, P. (2007). Complete Nucleotide Sequence of the pCTX-M3 Plasmid and Its Involvement in Spread of the Extended-Spectrum {beta}-Lactamase Gene blaCTX-M-3. Antimicrob. Agents Chemother. 51: 3789-3795 [Abstract] [Full Text]
Ahmed, A. M., Motoi, Y., Sato, M., Maruyama, A., Watanabe, H., Fukumoto, Y., Shimamoto, T. (2007). Zoo Animals as Reservoirs of Gram-Negative Bacteria Harboring Integrons and Antimicrobial Resistance Genes. Appl. Environ. Microbiol. 73: 6686-6690 [Abstract] [Full Text]
Peralta, G., Sanchez, M. B., Garrido, J. C., De Benito, I., Cano, M. E., Martinez-Martinez, L., Roiz, M. P. (2007). Impact of antibiotic resistance and of adequate empirical antibiotic treatment in the prognosis of patients with Escherichia coli bacteraemia. J Antimicrob Chemother 60: 855-863 [Abstract] [Full Text]
Perilli, M., Celenza, G., Fiore, M., Segatore, B., Pellegrini, C., Luzzaro, F., Rossolini, G. M., Amicosante, G. (2007). Biochemical analysis of TEM-134, a new TEM-type extended-spectrum {beta}-lactamase variant produced in a Citrobacter koseri clinical isolate from an Italian hospital. J Antimicrob Chemother 60: 877-880 [Abstract] [Full Text]
Zhu, L.-X., Zhang, Z.-W., Liang, D., Jiang, D., Wang, C., Du, N., Zhang, Q., Mitchelson, K., Cheng, J. (2007). Multiplex Asymmetric PCR-Based Oligonucleotide Microarray for Detection of Drug Resistance Genes Containing Single Mutations in Enterobacteriaceae. Antimicrob. Agents Chemother. 51: 3707-3713 [Abstract] [Full Text]
Kim, T.-E., Jeong, Y.-W., Cho, S.-H., Kim, S.-J., Kwon, H.-J. (2007). Chronological Study of Antibiotic Resistances and Their Relevant Genes in Korean Avian Pathogenic Escherichia coli Isolates. J. Clin. Microbiol. 45: 3309-3315 [Abstract] [Full Text]
Arpin, C., Coulange, L., Dubois, V., Andre, C., Fischer, I., Fourmaux, S., Grobost, F., Jullin, J., Dutilh, B., Couture, J.-F., Noury, P., Lagrange, I., Ducastaing, A., Doermann, H.-P., Quentin, C. (2007). Extended-Spectrum-{beta}-Lactamase-Producing Enterobacteriaceae Strains in Various Types of Private Health Care Centers. Antimicrob. Agents Chemother. 51: 3440-3444 [Abstract] [Full Text]
Queenan, A. M., Shang, W., Kania, M., Page, M. G. P., Bush, K. (2007). Interactions of Ceftobiprole with {beta}-Lactamases from Molecular Classes A to D. Antimicrob. Agents Chemother. 51: 3089-3095 [Abstract] [Full Text]
Yang, K., Guglielmo, B J. (2007). Diagnosis and Treatment of Extended-Spectrum and AmpC {beta}-Lactamase-Producing Organisms. The Annals of Pharmacotherapy 41: 1427-1435 [Abstract] [Full Text]
Pallecchi, L., Bartoloni, A., Fiorelli, C., Mantella, A., Di Maggio, T., Gamboa, H., Gotuzzo, E., Kronvall, G., Paradisi, F., Rossolini, G. M. (2007). Rapid Dissemination and Diversity of CTX-M Extended-Spectrum {beta}-Lactamase Genes in Commensal Escherichia coli Isolates from Healthy Children from Low-Resource Settings in Latin America. Antimicrob. Agents Chemother. 51: 2720-2725 [Abstract] [Full Text]
Girlich, D., Poirel, L., Carattoli, A., Kempf, I., Lartigue, M.-F., Bertini, A., Nordmann, P. (2007). Extended-Spectrum {beta}-Lactamase CTX-M-1 in Escherichia coli Isolates from Healthy Poultry in France. Appl. Environ. Microbiol. 73: 4681-4685 [Abstract] [Full Text]
Power, P., Di Conza, J., Rodriguez, M. M., Ghiglione, B., Ayala, J. A., Casellas, J. M., Radice, M., Gutkind, G. (2007). Biochemical Characterization of PER-2 and Genetic Environment of blaPER-2. Antimicrob. Agents Chemother. 51: 2359-2365 [Abstract] [Full Text]
Tumbarello, M., Sanguinetti, M., Montuori, E., Trecarichi, E. M., Posteraro, B., Fiori, B., Citton, R., D'Inzeo, T., Fadda, G., Cauda, R., Spanu, T. (2007). Predictors of Mortality in Patients with Bloodstream Infections Caused by Extended-Spectrum-{beta}-Lactamase-Producing Enterobacteriaceae: Importance of Inadequate Initial Antimicrobial Treatment. Antimicrob. Agents Chemother. 51: 1987-1994 [Abstract] [Full Text]
Fernandez, A., Gil, E., Cartelle, M., Perez, A., Beceiro, A., Mallo, S., Tomas, M. M., Perez-Llarena, F. J., Villanueva, R., Bou, G. (2007). Interspecies spread of CTX-M-32 extended-spectrum {beta}-lactamase and the role of the insertion sequence IS1 in down-regulating blaCTX-M gene expression. J Antimicrob Chemother 59: 841-847 [Abstract] [Full Text]
Bell, J. M., Chitsaz, M., Turnidge, J. D., Barton, M., Walters, L. J., Jones, R. N. (2007). Prevalence and Significance of a Negative Extended-Spectrum {beta}-Lactamase (ESBL) Confirmation Test Result after a Positive ESBL Screening Test Result for Isolates of Escherichia coli and Klebsiella pneumoniae: Results from the SENTRY Asia-Pacific Surveillance Program. J. Clin. Microbiol. 45: 1478-1482 [Abstract] [Full Text]
Wu, L.-T., Chang, S.-Y., Yen, M.-R., Yang, T.-C., Tseng, Y.-H. (2007). Characterization of Extended-Host-Range Pseudo-T-Even Bacteriophage Kpp95 Isolated on Klebsiella pneumoniae. Appl. Environ. Microbiol. 73: 2532-2540 [Abstract] [Full Text]
Tristram, S., Jacobs, M. R., Appelbaum, P. C. (2007). Antimicrobial Resistance in Haemophilus influenzae. Clin. Microbiol. Rev. 20: 368-389 [Abstract] [Full Text]
Zienkiewicz, M., Kern-Zdanowicz, I., Golebiewski, M., Zylinska, J., Mieczkowski, P., Gniadkowski, M., Bardowski, J., Ceglowski, P. (2007). Mosaic Structure of p1658/97, a 125-Kilobase Plasmid Harboring an Active Amplicon with the Extended-Spectrum {beta}-Lactamase Gene blaSHV-5. Antimicrob. Agents Chemother. 51: 1164-1171 [Abstract] [Full Text]
Song, W., Bae, I. K., Lee, Y.-N., Lee, C.-H., Lee, S. H., Jeong, S. H. (2007). Detection of Extended-Spectrum {beta}-Lactamases by Using Boronic Acid as an AmpC {beta}-Lactamase Inhibitor in Clinical Isolates of Klebsiella spp. and Escherichia coli. J. Clin. Microbiol. 45: 1180-1184 [Abstract] [Full Text]
Sidjabat, H. E., Hanson, N. D., Smith-Moland, E., Bell, J. M., Gibson, J. S., Filippich, L. J., Trott, D. J. (2007). Identification of plasmid-mediated extended-spectrum and AmpC {beta}-lactamases in Enterobacter spp. isolated from dogs. J Med Microbiol 56: 426-434 [Abstract] [Full Text]
Glupczynski, Y., Berhin, C., Bauraing, C., Bogaerts, P. (2007). Evaluation of a New Selective Chromogenic Agar Medium for Detection of Extended-Spectrum {beta}-Lactamase-Producing Enterobacteriaceae. J. Clin. Microbiol. 45: 501-505 [Abstract] [Full Text]
Schmitt, J., Jacobs, E., Schmidt, H. (2007). Molecular characterization of extended-spectrum beta-lactamases in Enterobacteriaceae from patients of two hospitals in Saxony, Germany. J Med Microbiol 56: 241-249 [Abstract] [Full Text]
Naas, T., Oxacelay, C., Nordmann, P. (2007). Identification of CTX-M-Type Extended-Spectrum-{beta}-Lactamase Genes Using Real-Time PCR and Pyrosequencing. Antimicrob. Agents Chemother. 51: 223-230 [Abstract] [Full Text]
Ahmed, A. M., Furuta, K., Shimomura, K., Kasama, Y., Shimamoto, T. (2006). Genetic characterization of multidrug resistance in Shigella spp. from Japan.. J Med Microbiol 55: 1685-1691 [Abstract] [Full Text]
Mamlouk, K., Boutiba-Ben Boubaker, I., Gautier, V., Vimont, S., Picard, B., Ben Redjeb, S., Arlet, G. (2006). Emergence and Outbreaks of CTX-M {beta}-Lactamase-Producing Escherichia coli and Klebsiella pneumoniae Strains in a Tunisian Hospital. J. Clin. Microbiol. 44: 4049-4056 [Abstract] [Full Text]
al Naiemi, N., Duim, B., Bart, A. (2006). A CTX-M extended-spectrum {beta}-lactamase in Pseudomonas aeruginosa and Stenotrophomonas maltophilia.. J Med Microbiol 55: 1607-1608 [Full Text]
Chouchani, C., Berlemont, R., Masmoudi, A., Galleni, M., Frere, J.-M., Belhadj, O., Ben-Mahrez, K. (2006). A Novel Extended-Spectrum TEM-Type {beta}-Lactamase, TEM-138, from Salmonella enterica Serovar Infantis.. Antimicrob. Agents Chemother. 50: 3183-3185 [Abstract] [Full Text]
Spanu, T., Sanguinetti, M., Tumbarello, M., D'Inzeo, T., Fiori, B., Posteraro, B., Santangelo, R., Cauda, R., Fadda, G. (2006). Evaluation of the New VITEK 2 Extended-Spectrum Beta-Lactamase (ESBL) Test for Rapid Detection of ESBL Production in Enterobacteriaceae Isolates.. J. Clin. Microbiol. 44: 3257-3262 [Abstract] [Full Text]
Mugnaioli, C., Luzzaro, F., De Luca, F., Brigante, G., Perilli, M., Amicosante, G., Stefani, S., Toniolo, A., Rossolini, G. M. (2006). CTX-M-Type Extended-Spectrum {beta}-Lactamases in Italy: Molecular Epidemiology of an Emerging Countrywide Problem.. Antimicrob. Agents Chemother. 50: 2700-2706 [Abstract] [Full Text]
Novais, A., Canton, R., Valverde, A., Machado, E., Galan, J.-C., Peixe, L., Carattoli, A., Baquero, F., Coque, T. M. (2006). Dissemination and Persistence of blaCTX-M-9 Are Linked to Class 1 Integrons Containing CR1 Associated with Defective Transposon Derivatives from Tn402 Located in Early Antibiotic Resistance Plasmids of IncHI2, IncP1-{alpha}, and IncFI Groups.. Antimicrob. Agents Chemother. 50: 2741-2750 [Abstract] [Full Text]
Fonseca, E. L., Mykytczuk, O. L., Asensi, M. D., Reis, E. M. F., Ferraz, L. R., Paula, F. L., Ng, L. K., Rodrigues, D. P. (2006). Clonality and Antimicrobial Resistance Gene Profiles of Multidrug- Resistant Salmonella enterica Serovar Infantis Isolates from Four Public Hospitals in Rio de Janeiro, Brazil.. J. Clin. Microbiol. 44: 2767-2772 [Abstract] [Full Text]
Mena, A., Plasencia, V., Garcia, L., Hidalgo, O., Ayestaran, J. I., Alberti, S., Borrell, N., Perez, J. L., Oliver, A. (2006). Characterization of a Large Outbreak by CTX-M-1-Producing Klebsiella pneumoniae and Mechanisms Leading to In Vivo Carbapenem Resistance Development.. J. Clin. Microbiol. 44: 2831-2837 [Abstract] [Full Text]
al Naiemi, N., Bart, A., de Jong, M. D., Vandenbroucke-Grauls, C. M., Rietra, P. J. G. M., Debets-Ossenkopp, Y. J., Wever, P. C., Spanjaard, L., Bos, A. J., Duim, B. (2006). Widely Distributed and Predominant CTX-M Extended-Spectrum {beta}-Lactamases in Amsterdam, The Netherlands.. J. Clin. Microbiol. 44: 3012-3014 [Abstract] [Full Text]
Lavollay, M., Mamlouk, K., Frank, T., Akpabie, A., Burghoffer, B., Ben Redjeb, S., Bercion, R., Gautier, V., Arlet, G. (2006). Clonal Dissemination of a CTX-M-15 {beta}-Lactamase-Producing Escherichia coli Strain in the Paris Area, Tunis, and Bangui.. Antimicrob. Agents Chemother. 50: 2433-2438 [Abstract] [Full Text]
Cleven, B. E. E., Palka-Santini, M., Gielen, J., Meembor, S., Kronke, M., Krut, O. (2006). Identification and characterization of bacterial pathogens causing bloodstream infections by DNA microarray.. J. Clin. Microbiol. 44: 2389-2397 [Abstract] [Full Text]
Davis, K. A. (2006). Ventilator-associated pneumonia: a review.. J Intensive Care Med 21: 211-226 [Abstract]
Mesa, R. J., Blanc, V., Blanch, A. R., Cortes, P., Gonzalez, J. J., Lavilla, S., Miro, E., Muniesa, M., Saco, M., Tortola, M. T., Mirelis, B., Coll, P., Llagostera, M., Prats, G., Navarro, F. (2006). Extended-spectrum {beta}-lactamase-producing Enterobacteriaceae in different environments (humans, food, animal farms and sewage). J Antimicrob Chemother 58: 211-215 [Abstract] [Full Text]
Yan, J.-J., Hsueh, P.-R., Lu, J.-J., Chang, F.-Y., Shyr, J.-M., Wan, J.-H., Liu, Y.-C., Chuang, Y.-C., Yang, Y.-C., Tsao, S.-M., Wu, H.-H., Wang, L.-S., Lin, T.-P., Wu, H.-M., Chen, H.-M., Wu, J.-J. (2006). Extended-Spectrum {beta}-Lactamases and Plasmid-Mediated AmpC Enzymes among Clinical Isolates of Escherichia coli and Klebsiella pneumoniae from Seven Medical Centers in Taiwan.. Antimicrob. Agents Chemother. 50: 1861-1864 [Abstract] [Full Text]
Luzzaro, F., Mezzatesta, M., Mugnaioli, C., Perilli, M., Stefani, S., Amicosante, G., Rossolini, G. M., Toniolo, A. (2006). Trends in Production of Extended-Spectrum {beta}-Lactamases among Enterobacteria of Medical Interest: Report of the Second Italian Nationwide Survey.. J. Clin. Microbiol. 44: 1659-1664 [Abstract] [Full Text]
al Naiemi, N., Schipper, K., Duim, B., Bart, A. (2006). Application of Minimal Sequence Quality Values Prevents Misidentification of the blaSHV Type in Single Bacterial Isolates Carrying Different SHV Extended-Spectrum {beta}-Lactamase Genes.. J. Clin. Microbiol. 44: 1896-1898 [Abstract] [Full Text]
Bagattini, M., Crivaro, V., Di Popolo, A., Gentile, F., Scarcella, A., Triassi, M., Villari, P., Zarrilli, R. (2006). Molecular epidemiology of extended-spectrum {beta}-lactamase-producing Klebsiella pneumoniae in a neonatal intensive care unit. J Antimicrob Chemother 57: 979-982 [Abstract] [Full Text]
Schwaber, M. J., Navon-Venezia, S., Kaye, K. S., Ben-Ami, R., Schwartz, D., Carmeli, Y. (2006). Clinical and Economic Impact of Bacteremia with Extended- Spectrum-{beta}-Lactamase-Producing Enterobacteriaceae.. Antimicrob. Agents Chemother. 50: 1257-1262 [Abstract] [Full Text]
Bozdogan, B., Tristram, S., Appelbaum, P. C. (2006). Combination of altered PBPs and expression of cloned extended-spectrum {beta}-lactamases confers cefotaxime resistance in Haemophilus influenzae. J Antimicrob Chemother 57: 747-749 [Abstract] [Full Text]
Dashti, A. A., West, P., Paton, R., Amyes, S. G. B. (2006). Characterization of extended-spectrum {beta}-lactamase (ESBL)-producing Kuwait and UK strains identified by the Vitek system, and subsequent comparison of the Vitek system with other commercial ESBL-testing systems using these strains.. J Med Microbiol 55: 417-421 [Abstract] [Full Text]
Sturenburg, E., Storm, N., Sobottka, I., Horstkotte, M. A., Scherpe, S., Aepfelbacher, M., Muller, S. (2006). Detection and Genotyping of SHV {beta}-Lactamase Variants by Mass Spectrometry after Base-Specific Cleavage of In Vitro-Generated RNA Transcripts.. J. Clin. Microbiol. 44: 909-915 [Abstract] [Full Text]
Fujii, R., Kitaoka, M., Hayashi, K. (2006). RAISE: a simple and novel method of generating random insertion and deletion mutations. Nucleic Acids Res 34: e30-e30 [Abstract] [Full Text]
Tumbarello, M., Spanu, T., Sanguinetti, M., Citton, R., Montuori, E., Leone, F., Fadda, G., Cauda, R. (2006). Bloodstream Infections Caused by Extended-Spectrum-{beta}-Lactamase-Producing Klebsiella pneumoniae: Risk Factors, Molecular Epidemiology, and Clinical Outcome. Antimicrob. Agents Chemother. 50: 498-504 [Abstract] [Full Text]
Verdet, C., Benzerara, Y., Gautier, V., Adam, O., Ould-Hocine, Z., Arlet, G. (2006). Emergence of DHA-1-Producing Klebsiella spp. in the Parisian Region: Genetic Organization of the ampC and ampR Genes Originating from Morganella morganii. Antimicrob. Agents Chemother. 50: 607-617 [Abstract] [Full Text]
D'Andrea, M. M., Nucleo, E., Luzzaro, F., Giani, T., Migliavacca, R., Vailati, F., Kroumova, V., Pagani, L., Rossolini, G. M. (2006). CMY-16, a Novel Acquired AmpC-Type {beta}-Lactamase of the CMY/LAT Lineage in Multifocal Monophyletic Isolates of Proteus mirabilis from Northern Italy. Antimicrob. Agents Chemother. 50: 618-624 [Abstract] [Full Text]
Shibata, N., Kurokawa, H., Doi, Y., Yagi, T., Yamane, K., Wachino, J.-i., Suzuki, S., Kimura, K., Ishikawa, S., Kato, H., Ozawa, Y., Shibayama, K., Kai, K., Konda, T., Arakawa, Y. (2006). PCR Classification of CTX-M-Type {beta}-Lactamase Genes Identified in Clinically Isolated Gram-Negative Bacilli in Japan. Antimicrob. Agents Chemother. 50: 791-795 [Abstract] [Full Text]
Eckert, C., Gautier, V., Arlet, G. (2006). DNA sequence analysis of the genetic environment of various blaCTX-M genes. J Antimicrob Chemother 57: 14-23 [Abstract] [Full Text]
Soge, O. O., Queenan, A. M., Ojo, K. K., Adeniyi, B. A., Roberts, M. C. (2006). CTX-M-15 extended-spectrum {beta}-lactamase from Nigerian Klebsiella pneumoniae. J Antimicrob Chemother 57: 24-30 [Abstract] [Full Text]
Brinas, L., Lantero, M., de Diego, I., Alvarez, M., Zarazaga, M., Torres, C. (2005). Mechanisms of resistance to expanded-spectrum cephalosporins in Escherichia coli isolates recovered in a Spanish hospital. J Antimicrob Chemother 56: 1107-1110 [Abstract] [Full Text]
Miro, E., Mirelis, B., Navarro, F., Rivera, A., Mesa, R. J., Roig, M. C., Gomez, L., Coll, P. (2005). Surveillance of extended-spectrum {beta}-lactamases from clinical samples and faecal carriers in Barcelona, Spain. J Antimicrob Chemother 56: 1152-1155 [Abstract] [Full Text]
Pitout, J. D. D., Laupland, K. B., Church, D. L., Menard, M. L., Johnson, J. R. (2005). Virulence Factors of Escherichia coli Isolates That Produce CTX-M-Type Extended-Spectrum {beta}-Lactamases. Antimicrob. Agents Chemother. 49: 4667-4670 [Abstract] [Full Text]
Szabo, D., Melan, M. A., Hujer, A. M., Bonomo, R. A., Hujer, K. M., Bethel, C. R., Kristof, K., Paterson, D. L. (2005). Molecular Analysis of the Simultaneous Production of Two SHV-Type Extended-Spectrum Beta-Lactamases in a Clinical Isolate of Enterobacter cloacae by Using Single-Nucleotide Polymorphism Genotyping. Antimicrob. Agents Chemother. 49: 4716-4720 [Abstract] [Full Text]
Chmelnitsky, I., Carmeli, Y., Leavitt, A., Schwaber, M. J., Navon-Venezia, S. (2005). CTX-M-2 and a New CTX-M-39 Enzyme Are the Major Extended-Spectrum Beta-Lactamases in Multiple Escherichia coli Clones Isolated in Tel Aviv, Israel. Antimicrob. Agents Chemother. 49: 4745-4750 [Abstract] [Full Text]
Baquero, M.-R., Galan, J. C., del Carmen Turrientes, M., Canton, R., Coque, T. M., Martinez, J. L., Baquero, F. (2005). Increased Mutation Frequencies in Escherichia coli Isolates Harboring Extended-Spectrum {beta}-Lactamases. Antimicrob. Agents Chemother. 49: 4754-4756 [Abstract] [Full Text]
Alba, J., Ishii, Y., Thomson, K., Moland, E. S., Yamaguchi, K. (2005). Kinetics Study of KPC-3, a Plasmid-Encoded Class A Carbapenem-Hydrolyzing {beta}-Lactamase. Antimicrob. Agents Chemother. 49: 4760-4762 [Abstract] [Full Text]
Jeong, S. H., Bae, I. K., Kim, D., Hong, S. G., Song, J. S., Lee, J. H., Lee, S. H. (2005). First Outbreak of Klebsiella pneumoniae Clinical Isolates Producing GES-5 and SHV-12 Extended-Spectrum {beta}-Lactamases in Korea. Antimicrob. Agents Chemother. 49: 4809-4810 [Full Text]
Padayatti, P. S., Helfand, M. S., Totir, M. A., Carey, M. P., Carey, P. R., Bonomo, R. A., van den Akker, F. (2005). High Resolution Crystal Structures of the trans-Enamine Intermediates Formed by Sulbactam and Clavulanic Acid and E166A SHV-1 {beta}-Lactamase. J. Biol. Chem. 280: 34900-34907 [Abstract] [Full Text]
Paterson, D. L., Bonomo, R. A. (2005). Extended-Spectrum {beta}-Lactamases: a Clinical Update. Clin. Microbiol. Rev. 18: 657-686 [Abstract] [Full Text]
Petersen, P. J., Bradford, P. A. (2005). Effect of Medium Age and Supplementation with the Biocatalytic Oxygen-Reducing Reagent Oxyrase on In Vitro Activities of Tigecycline against Recent Clinical Isolates. Antimicrob. Agents Chemother. 49: 3910-3918 [Abstract] [Full Text]
Chia, J.-H., Chu, C., Su, L.-H., Chiu, C.-H., Kuo, A.-J., Sun, C.-F., Wu, T.-L. (2005). Development of a Multiplex PCR and SHV Melting-Curve Mutation Detection System for Detection of Some SHV and CTX-M {beta}-Lactamases of Escherichia coli, Klebsiella pneumoniae, and Enterobacter cloacae in Taiwan. J. Clin. Microbiol. 43: 4486-4491 [Abstract] [Full Text]
Naiemi, N. A., Duim, B., Savelkoul, P. H. M., Spanjaard, L., de Jonge, E., Bart, A., Vandenbroucke-Grauls, C. M., de Jong, M. D. (2005). Widespread Transfer of Resistance Genes between Bacterial Species in an Intensive Care Unit: Implications for Hospital Epidemiology. J. Clin. Microbiol. 43: 4862-4864 [Abstract] [Full Text]
Livermore, D. M., Hawkey, P. M. (2005). CTX-M: changing the face of ESBLs in the UK. J Antimicrob Chemother 56: 451-454 [Abstract] [Full Text]
Mantengoli, E., Rossolini, G. M. (2005). Tn5393d, a Complex Tn5393 Derivative Carrying the PER-1 Extended-Spectrum {beta}-Lactamase Gene and Other Resistance Determinants. Antimicrob. Agents Chemother. 49: 3289-3296 [Abstract] [Full Text]
Aubert, D., Naas, T., Lartigue, M.-F., Nordmann, P. (2005). Novel Genetic Structure Associated with an Extended-Spectrum {beta}-Lactamase blaVEB Gene in a Providencia stuartii Clinical Isolate from Algeria. Antimicrob. Agents Chemother. 49: 3590-3592 [Abstract] [Full Text]
Mugnaioli, C., Luzzaro, F., De Luca, F., Brigante, G., Amicosante, G., Rossolini, G. M. (2005). Dissemination of CTX-M-Type Extended-Spectrum {beta}-Lactamase Genes to Unusual Hosts. J. Clin. Microbiol. 43: 4183-4185 [Abstract] [Full Text]

Antimicrob. Agents Chemother.	Clin. Vaccine Immunol.
J. Clin. Microbiol.	ALL ASM JOURNALS

Extended-Spectrum -Lactamases in the 21st Century: Characterization, Epidemiology, and Detection of This Important Resistance Threat

Extended-Spectrum $beta$ -Lactamases in the 21st Century: Characterization, Epidemiology, and Detection of This Important Resistance Threat