Aspergillus fumigatus and Aspergillosis

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Clinical Microbiology Reviews, April 1999, p. 310-350, Vol. 12, No. 2
0893-8512/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Aspergillus fumigatus and Aspergillosis

Jean-Paul Latgé^*

Laboratoire des Aspergillus, Institut Pasteur, 75015 Paris, France

Aspergillus fumigatus is one of the most ubiquitous of the airborne saprophytic fungi. Humans and animals constantly inhalenumerous conidia of this fungus. The conidia are normally eliminatedin the immunocompetent host by innate immune mechanisms, and aspergillomaand allergic bronchopulmonary aspergillosis, uncommon clinicalsyndromes, are the only infections observed in such hosts. Thus,A. fumigatus was considered for years to be a weak pathogen. Withincreases in the number of immunosuppressed patients, however,there has been a dramatic increase in severe and usually fatalinvasive aspergillosis, now the most common mold infection worldwide.In this review, the focus is on the biology of A. fumigatus andthe diseases it causes. Included are discussions of (i) genomicand molecular characterization of the organism, (ii) clinicaland laboratory methods available for the diagnosis of aspergillosisin immunocompetent and immunocompromised hosts, (iii) identificationof host and fungal factors that play a role in the establishmentof the fungus in vivo, and (iv) problems associated with antifungaltherapy.

^* Mailing address: Laboratoire des Aspergillus, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France. Phone:01 40 61 35 18. Fax: 01 40 61 34 19. E-mail: jplatge{at}pasteur.fr.

Clinical Microbiology Reviews, April 1999, p. 310-350, Vol. 12, No. 2
0893-8512/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

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Elzi, L., Laifer, G., Bremerich, J., Vosbeck, J., Mayr, M. (2005). Invasive apergillosis with myocardial involvement after kidney transplantation. Nephrol Dial Transplant 20: 631-634 [Full Text]
Gomez-Lopez, A., Aberkane, A., Petrikkou, E., Mellado, E., Rodriguez-Tudela, J. L., Cuenca-Estrella, M. (2005). Analysis of the Influence of Tween Concentration, Inoculum Size, Assay Medium, and Reading Time on Susceptibility Testing of Aspergillus spp.. J. Clin. Microbiol. 43: 1251-1255 [Abstract] [Full Text]
Xiong, Q., Hassan, S. A., Wilson, W. K., Han, X. Y., May, G. S., Tarrand, J. J., Matsuda, S. P. T. (2005). Cholesterol Import by Aspergillus fumigatus and Its Influence on Antifungal Potency of Sterol Biosynthesis Inhibitors. Antimicrob. Agents Chemother. 49: 518-524 [Abstract] [Full Text]
Trama, J. P., Mordechai, E., Adelson, M. E. (2005). Detection of Aspergillus fumigatus and a Mutation That Confers Reduced Susceptibility to Itraconazole and Posaconazole by Real-Time PCR and Pyrosequencing. J. Clin. Microbiol. 43: 906-908 [Abstract] [Full Text]
Kamai, Y., Kakuta, M., Shibayama, T., Fukuoka, T., Kuwahara, S. (2005). Antifungal Activities of R-135853, a Sordarin Derivative, in Experimental Candidiasis in Mice. Antimicrob. Agents Chemother. 49: 52-56 [Abstract] [Full Text]
Singh, N., Paterson, D. L. (2005). Aspergillus Infections in Transplant Recipients. Clin. Microbiol. Rev. 18: 44-69 [Abstract] [Full Text]
Mukherjee, P. K., Sheehan, D. J., Hitchcock, C. A., Ghannoum, M. A. (2005). Combination Treatment of Invasive Fungal Infections. Clin. Microbiol. Rev. 18: 163-194 [Abstract] [Full Text]
Stephens-Romero, S. D., Mednick, A. J., Feldmesser, M. (2005). The Pathogenesis of Fatal Outcome in Murine Pulmonary Aspergillosis Depends on the Neutrophil Depletion Strategy. Infect. Immun. 73: 114-125 [Abstract] [Full Text]
Balloy, V., Huerre, M., Latge, J.-P., Chignard, M. (2005). Differences in Patterns of Infection and Inflammation for Corticosteroid Treatment and Chemotherapy in Experimental Invasive Pulmonary Aspergillosis. Infect. Immun. 73: 494-503 [Abstract] [Full Text]
Chen, J., Li, H., Li, R., Bu, D., Wan, Z. (2005). Mutations in the cyp51A gene and susceptibility to itraconazole in Aspergillus fumigatus serially isolated from a patient with lung aspergilloma. J Antimicrob Chemother 55: 31-37 [Abstract] [Full Text]
Gaziano, R., Bozza, S., Bellocchio, S., Perruccio, K., Montagnoli, C., Pitzurra, L., Salvatori, G., De Santis, R., Carminati, P., Mantovani, A., Romani, L. (2004). Anti-Aspergillus fumigatus Efficacy of Pentraxin 3 Alone and in Combination with Antifungals. Antimicrob. Agents Chemother. 48: 4414-4421 [Abstract] [Full Text]
Schrettl, M., Bignell, E., Kragl, C., Joechl, C., Rogers, T., Arst, H. N. Jr., Haynes, K., Haas, H. (2004). Siderophore Biosynthesis But Not Reductive Iron Assimilation Is Essential for Aspergillus fumigatus Virulence. J. Exp. Med. 200: 1213-1219 [Abstract] [Full Text]
Serrano-Gomez, D., Dominguez-Soto, A., Ancochea, J., Jimenez-Heffernan, J. A., Leal, J. A., Corbi, A. L. (2004). Dendritic Cell-Specific Intercellular Adhesion Molecule 3-Grabbing Nonintegrin Mediates Binding and Internalization of Aspergillus fumigatus Conidia by Dendritic Cells and Macrophages. J. Immunol. 173: 5635-5643 [Abstract] [Full Text]
Imai, J. K., Singh, G., Clemons, K. V., Stevens, D. A. (2004). Efficacy of Posaconazole in a Murine Model of Central Nervous System Aspergillosis. Antimicrob. Agents Chemother. 48: 4063-4066 [Abstract] [Full Text]
Yekutiel, A., Shalit, I., Shadkchan, Y., Osherov, N. (2004). In Vitro Activity of Caspofungin Combined with Sulfamethoxazole against Clinical Isolates of Aspergillus spp.. Antimicrob. Agents Chemother. 48: 3279-3283 [Abstract] [Full Text]
Liebmann, B., Muller, M., Braun, A., Brakhage, A. A. (2004). The Cyclic AMP-Dependent Protein Kinase A Network Regulates Development and Virulence in Aspergillus fumigatus. Infect. Immun. 72: 5193-5203 [Abstract] [Full Text]

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